Review Article Erratic behavior of nitric oxide within the immune system: illustrative review of conflicting data and their immunopharmacological aspects
Identifieur interne : 001194 ( Main/Exploration ); précédent : 001193; suivant : 001195Review Article Erratic behavior of nitric oxide within the immune system: illustrative review of conflicting data and their immunopharmacological aspects
Auteurs : Z. Zidek [République tchèque] ; K. Mašek [République tchèque]Source :
- International Journal of Immunopharmacology [ 0192-0561 ] ; 1998.
English descriptors
- Teeft :
- Acad, Albina, Antigen expression, Apoptosis, Arginase, Arginase activity, Arginine, Biochem, Biol, Biophys, Chem, Clin, Colitis, Commun, Cyclic, Cytokine, Cytolytic, Cytotoxic, Cytotoxicity, Czech republic, Encephalomyelitis, Endogenous, Endogenous nitric oxide, Endothelial, Endothelial cells, Endotoxemia, Hepatocytes, Hibbs, Human macrophages, Human monocytes, Immune, Immunol, Inducible, Inducible nitric oxide synthase, Inhibition, Inhibitor, Inos, Inos activity, Inos mrna, Interferon, Interleukin, Intracellular, Karupiah, Leishmania, Lett, Leukoc, Leukocyte, Liew, Lipopolysaccharide, Macrophage, Mediator, Metastasis, Mitochondrial respiration, Moncada, Monocyte, Mrna, Murine, Murine macrophages, Muscle cells, Natl, Nitric, Nitric oxide, Nitric oxide production, Nitric oxide synthase, Nitric oxide synthase activity, Nitric oxide synthase inhibition, Nitric oxide synthesis, Nitrite, Ornithine, Oxide, Pathway, Peritoneal, Peritoneal macrophages, Peroxynitrite, Pharmacol, Physiol, Proc, Prostaglandin, Reactive, Replication, Sato, Stuehr, Synthase, Thomsen, Tumor cells, Tumor growth, Tumor necrosis factor, Ulcerative colitis, Zidek.
Abstract
Abstract: The literature data assembled in this article document the variation of immunobiological effects of nitric oxide (NO). A number of factors are obviously responsible for the diversity, ranging from inactivity, alleviation, but not rarely to exacerbation of certain pathogenetic processes. A better understanding of NO interactions with the immune system can only be reached if more complex experimental designs to study the effects of reactive nitrogen species are adopted in the future. They should integrate major participating variables and take into account pharmacodynamic\kinetic aspects of NO production in triggering the ultimate effects. If manipulation of NO in the organism by means of recently developed NO inhibitors and NO donors is to become a rational tool of immunopharmacological strategies, detailed knowledge of their pharmacologies and toxicologies is urgently needed in order to differentiate between the effects of NO and other side effects. Hopefully, this approach could improve the predictability of the clinical outcomes of NO manipulation.
Url:
DOI: 10.1016/S0192-0561(98)00036-8
Affiliations:
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A number of factors are obviously responsible for the diversity, ranging from inactivity, alleviation, but not rarely to exacerbation of certain pathogenetic processes. A better understanding of NO interactions with the immune system can only be reached if more complex experimental designs to study the effects of reactive nitrogen species are adopted in the future. They should integrate major participating variables and take into account pharmacodynamic\kinetic aspects of NO production in triggering the ultimate effects. If manipulation of NO in the organism by means of recently developed NO inhibitors and NO donors is to become a rational tool of immunopharmacological strategies, detailed knowledge of their pharmacologies and toxicologies is urgently needed in order to differentiate between the effects of NO and other side effects. Hopefully, this approach could improve the predictability of the clinical outcomes of NO manipulation.</div></front></TEI><affiliations><list><country><li>République tchèque</li></country><region><li>Bohême centrale</li></region><settlement><li>Prague</li></settlement></list><tree><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Zidek, Z" sort="Zidek, Z" uniqKey="Zidek Z" first="Z." last="Zidek">Z. Zidek</name></region><name sortKey="Masek, K" sort="Masek, K" uniqKey="Masek K" first="K." last="Mašek">K. Mašek</name><name sortKey="Zidek, Z" sort="Zidek, Z" uniqKey="Zidek Z" first="Z." last="Zidek">Z. Zidek</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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